![](/CAS/GIF/132740-43-3.gif)
4-FLUOROBENZYL ISOCYANATE synthesis
- Product Name:4-FLUOROBENZYL ISOCYANATE
- CAS Number:132740-43-3
- Molecular formula:C8H6FNO
- Molecular Weight:151.14
![Triphosgene](/CAS/GIF/32315-10-9.gif)
32315-10-9
411 suppliers
$10.00/1g
![4-Fluorobenzylamine](/CAS/GIF/140-75-0.gif)
140-75-0
463 suppliers
$10.00/10g
![4-FLUOROBENZYL ISOCYANATE](/CAS/GIF/132740-43-3.gif)
132740-43-3
79 suppliers
$33.00/250mg
Yield: 100%
Reaction Conditions:
with triethylamine in dichloromethane
Steps:
General procedure C: preparation of N-alkyl-3-oxobenzo[d]isothiazole-2(3H)-carboxamide analogues 6a-w
General procedure: To a solution of triphosgene (2.96 g, 10 mmol) in DCM (20 ml) was added dropwise to primary amine 4 (10 mmol) in DCM (20 ml) followed by the dropwise addition of triethylamine (3 ml) in DCM (10 ml). The solvent was removed on a rotary evaporator. The resulting residue was dissolved in DCM (20 ml), and 1,2-benzisothiazol-3-one (1.51 g, 10 mmol) in THF (20 ml) was added. After the mixture was refluxed for 30 min, the solvent was removed on a rotary evaporator. The residue was dissolved in acetone (30 ml) and mixed with water (30 ml). The precipitate was collected on a funnel by vacuum filtration and washed with water-acetone (1:1,4 × 5 ml) to afford the final compound.
References:
Liu, Dazhi;Tian, Zhen;Yan, Zhihui;Wu, Lixin;Ma, Yan;Wang, Quan;Liu, Wei;Zhou, Honggang;Yang, Cheng [Bioorganic and Medicinal Chemistry,2013,vol. 21,# 11,p. 2960 - 2967]
![4-Fluorophenylacetic acid](/CAS/GIF/405-50-5.gif)
405-50-5
419 suppliers
$5.00/10g
![4-FLUOROBENZYL ISOCYANATE](/CAS/GIF/132740-43-3.gif)
132740-43-3
79 suppliers
$33.00/250mg
![4-Fluorophenylacetyl chloride](/CAS/GIF/459-04-1.gif)
459-04-1
145 suppliers
$10.00/5g
![4-FLUOROBENZYL ISOCYANATE](/CAS/GIF/132740-43-3.gif)
132740-43-3
79 suppliers
$33.00/250mg
![4-Fluorobenzylamine](/CAS/GIF/140-75-0.gif)
140-75-0
463 suppliers
$10.00/10g
![Diphosgene](/CAS/GIF/503-38-8.gif)
503-38-8
109 suppliers
$15.00/5g
![4-FLUOROBENZYL ISOCYANATE](/CAS/GIF/132740-43-3.gif)
132740-43-3
79 suppliers
$33.00/250mg