ChemicalBook CAS DataBase List (4-FLUOROPHENYLTHIO)ACETIC ACID

(4-FLUOROPHENYLTHIO)ACETIC ACID synthesis

6synthesis methods

Product Name:(4-FLUOROPHENYLTHIO)ACETIC ACID
CAS Number:332-51-4
Molecular formula:C8H7FO2S
Molecular Weight:186.2

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Yield: 0.78 g

Reaction Conditions:

with water;sodium hydroxide in ethanol at 40; for 1 h;

Steps:

Preparation of compound 2-(p-fluorophenylthiaoxy)acetic acid:
The crude product was added ethanol (10 ml) and 5% sodium hydroxide (8 ml). The addition is finished. At 40 °C, stir the reaction for 1h. The reaction is finished, the system reduced pressure distillation, to ethanol-free, residue adds the ice water (100 ml) and 5 wt % dilute hydrochloric acid (25 ml) acid, filter and wash the solid, column chromatography to obtain white solid compound 0.78g, yield 75%.

References:

Sichuan University of Science and Engineering;Cheng, Chunru CN106432153, 2017, A Location in patent:Paragraph 0032; 0033