ChemicalBook CAS DataBase List 4-FLUOROPHENYLUREA

4-FLUOROPHENYLUREA synthesis

10synthesis methods

Product Name:4-FLUOROPHENYLUREA
CAS Number:659-30-3
Molecular formula:C7H7FN2O
Molecular Weight:154.14

917-61-3 Synthesis

917-61-3
288 suppliers
$14.30/5g

371-40-4 Synthesis

371-40-4
404 suppliers
$5.00/5 g

659-30-3
61 suppliers
$33.39/250mg

Yield: 80.6%

Reaction Conditions:

with acetic acid in water at 50; for 2 h;

Steps:

4 General procedure for preparation of ureas (23a-m)
General procedure: To a solution of substituted aniline (0.1 mol) dissolved in 48 mL glacial acetic acid and 96 mL H2O, sodium cyanate (13 g, 0.2 mol) in warm water (90 mL) was added with continuous stirring. The mixture was warmed to 50 C for 2 h and then cooled in ice, The crude solid, thus obtained was filtered, dried, and recrystallized with boiling water.

References:

Liao, Weike;Hu, Gang;Guo, Zhuang;Sun, Deyu;Zhang, Lixia;Bu, Yanxin;Li, Yingxiu;Liu, Yajing;Gong, Ping [Bioorganic and Medicinal Chemistry,2015,vol. 23,# 15,p. 4410 - 4422]