![](/CAS/GIF/51660-65-2.gif)
4-IODO-1,3,5-TRIMETHYL-1H-PYRAZOLE synthesis
- Product Name:4-IODO-1,3,5-TRIMETHYL-1H-PYRAZOLE
- CAS Number:51660-65-2
- Molecular formula:C6H9IN2
- Molecular Weight:236.05
![3,5-Dimethyl-4-iodopyrazole](/CAS/GIF/2033-45-6.gif)
2033-45-6
150 suppliers
$6.00/1g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
341 suppliers
$15.00/10g
![4-IODO-1,3,5-TRIMETHYL-1H-PYRAZOLE](/CAS/GIF/51660-65-2.gif)
51660-65-2
49 suppliers
$39.00/250mg
Yield:51660-65-2 97%
Reaction Conditions:
Stage #1: 4-iodo-3,5-dimethyl-1H-pyrazolewith sodium hydride in tetrahydrofuran at 20;Inert atmosphere;
Stage #2: methyl iodide in tetrahydrofuran; for 12 h;
Steps:
4-Iodo-1,3,5-trimethyl-1H-pyrazole 6b
Under an atmosphere of nitrogen a solution of 4-iodo-3,5-dimethyl-1H-pyrazole (8.95 g; 40.0 mmol) inanhyd. THF was added dropwise to a freshly prepared suspension of sodium hydride (1.06 g; 44.0 mmol).The reaction mixture was stirred for 3 h and then 5.0 mL of methyl iodide (11.94 g; 88.0 mmol) were added dropwise. The mixture was stirred for additional 12 h and then quenched by adding approximately50 mL of water. The crude product was extracted with Et2O and dried over sodium sulfate. Afterevaporation of the solvent the product was obtained as a yellowish solid. Yield: 9.18 g (97%)
References:
Ahlburg, Nils Lennart;Doppleb, Olivia;Hillrichs, Kai;Namyslo, Jan C.;Hübner, Eike G.;Schmidt, Andreas [Heterocycles,2018,vol. 96,# 7,p. 1203 - 1215]
![1,3,5-Trimethylpyrazole](/CAS/GIF/1072-91-9.gif)
1072-91-9
236 suppliers
$5.00/25mg
![4-IODO-1,3,5-TRIMETHYL-1H-PYRAZOLE](/CAS/GIF/51660-65-2.gif)
51660-65-2
49 suppliers
$39.00/250mg
![3,5-Dimethylpyrazole](/CAS/GIF/67-51-6.gif)
67-51-6
537 suppliers
$6.00/25g
![4-IODO-1,3,5-TRIMETHYL-1H-PYRAZOLE](/CAS/GIF/51660-65-2.gif)
51660-65-2
49 suppliers
$39.00/250mg
![Acetylacetone](/CAS/GIF/123-54-6.gif)
123-54-6
565 suppliers
$10.00/25ml
![4-IODO-1,3,5-TRIMETHYL-1H-PYRAZOLE](/CAS/GIF/51660-65-2.gif)
51660-65-2
49 suppliers
$39.00/250mg
![4-AMINO-1,3,5-TRIMETHYLPYRAZOLE](/CAS/GIF/28466-21-9.gif)
28466-21-9
115 suppliers
$23.00/250mg
![4-IODO-1,3,5-TRIMETHYL-1H-PYRAZOLE](/CAS/GIF/51660-65-2.gif)
51660-65-2
49 suppliers
$39.00/250mg