ChemicalBook CAS DataBase List (4-IODO-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER

(4-IODO-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER synthesis

11synthesis methods

Product Name:(4-IODO-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS Number:189132-01-2
Molecular formula:C12H16INO2
Molecular Weight:333.17

24424-99-5 Synthesis

24424-99-5
824 suppliers
$13.50/25G

39959-59-6 Synthesis

39959-59-6
123 suppliers
$5.00/100mg

(4-IODO-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER

189132-01-2
27 suppliers
$95.34/0.25g

Yield: 99%

Reaction Conditions:

with sodium hydroxide in 1,4-dioxane;water at 20; for 18 h;

Steps:

1.A
A solution of 4-iodo-benzylamine (18.64g, 80mmol), dι'-tert-buty dicarbonate (19.21g, 88mmol), and NaOH (4.8Og, 120mmol) in dioxane/H2O (1 :1 , 25OmL) was stirred at room temp for 18 hours. The solvent was removed and the residue was dissolved in EtOAc (20OmL). The organic layer was washed with H2O (5OmL), HCl (IN, 2x 5OmL), NaHCO3 (10%, 5OmL) and H2O (5OmL). The organic solution was dried over anhydrous Na2SO4. The solvent was evaporated to give (4- iodobenzyl)carbamic acid tert-butyl ester (1, 26.5Og, 99%).

References:

CENGENT THERAPEUTICS, INC. WO2006/9876, 2006, A2 Location in patent:Page/Page column 139

68819-84-1 Synthesis