ChemicalBook CAS DataBase List (4-METHOXY-3-NITROPHENYL)ACETIC ACID

(4-METHOXY-3-NITROPHENYL)ACETIC ACID synthesis

13synthesis methods

Product Name:(4-METHOXY-3-NITROPHENYL)ACETIC ACID
CAS Number:63304-80-3
Molecular formula:C9H9NO5
Molecular Weight:211.17

4-METHOXY-3-NITRO-BENZENEACETIC ACID METHYL ESTER

34837-88-2
25 suppliers
$120.00/500mg

63304-80-3
16 suppliers
$189.00/100mg

Yield: 80%

Reaction Conditions:

with lithium hydroxide monohydrate in tetrahydrofuran;water at 20; for 1 h;

Steps:

17.3 Step 3. 2-(4-methoxy-3-nitrophenyl)acetic acid
Methyl 2-(4-methoxy-3-nitrophenyl)acetate (8.0 g, 35.6 mmol) was dissolved in tetrahydrofuran (80 mL) and water (20 mL). Lithium hydroxide monohydrate (4.5 g, 106.7 mmol) was slowly added to the reaction solution, and the reaction was stirred at room temperature for 1 hour. Tetrahydrofuran was removed under reduced pressure and the pH was adjusted to 3 with hydrochloric acid (3N). The reaction mixture was stirred for 15 minutes and then filtered. The filter cake was washed with 50 mL of water and dried to give 2-(4-methoxy-3-nitrophenypacetic acid. (6.0 g, 28.4 mmol, yield: 80%). ¹H NMR (400 MHz, DMSO-d₆) δ 12.46 (m, 1H), 7.79 (d, J=2.4 Hz, 1H), 7.56 (dd, J=2.4 and 8.8 Hz, 1H), 7.32 (d), J=8.8 Hz, 1H), 3.91(s, 3H), 3.64(s, 2H).

References:

Shanghai Zhimeng Biophama Co., Ltd.;CHEN, Huanming US2019/152963, 2019, A1 Location in patent:Paragraph 0290; 0297-0299

104-01-8 Synthesis