4-(methoxycarbonyl)-1-naphthoic acid synthesis
- Product Name:4-(methoxycarbonyl)-1-naphthoic acid
- CAS Number:21426-90-4
- Molecular formula:C13H10O4
- Molecular Weight:230.22
7487-15-2
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Yield:21426-90-4 92%
Reaction Conditions:
Stage #1: dimethyl 1,4-naphthalenedicarboxylatewith potassium hydroxide in tetrahydrofuran at 20; for 6 h;
Stage #2: with hydrogenchloride in water at 0;
Steps:
4 Example 4 Preparation of Compound (3) and Compound (4)
Add compound (2), namely 1,4-dimethyl naphthalate (30g, 122.8mmol) and THF (120mL) into a 1000mL round bottom flask,Stir to dissolve the solid, add KOH (11 g, 196.5 mmol), and react at room temperature for 6 hours. After the reaction, the temperature of the reaction solution was lowered to below 0°C, water (240 mL) was added, and it was washed twice with toluene (240 mL).Separate the liquids, slowly add 4mol/l hydrochloric acid (50mL) dropwise to the aqueous phase at 0°C. After the dropwise addition is complete, filter with suction.Obtained 26.0 g of white solid compound (4) with a yield of 92% and a purity of 96.2%;
References:
CN113354530,2021,A Location in patent:Paragraph 0088-0091
605-70-9
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