ChemicalBook CAS DataBase List 4-Methyl-2-oxopentanoic acid methyl ester

4-Methyl-2-oxopentanoic acid methyl ester synthesis

14synthesis methods

Product Name:4-Methyl-2-oxopentanoic acid methyl ester
CAS Number:3682-43-7
Molecular formula:C7H12O3
Molecular Weight:144.17

67-56-1 Synthesis

67-56-1
740 suppliers
$7.29/5ml-f

816-66-0 Synthesis

816-66-0
139 suppliers
$14.00/250mg

77-76-9
386 suppliers
$9.00/5ml

4-Methyl-2-oxopentanoic acid methyl ester

3682-43-7
62 suppliers
$65.00/100mg

Yield: 100%

Reaction Conditions:

with chloro-trimethyl-silane at 20;

Steps:

6
Intermediate Preparation 6; 4-Methyl-2-oxo-pentanoic acid methyl ester; To a solution of 4-methyl-2-oxo-pentanoic acid (3.4 g, 26 mmol) in methanol (12 mL) and 2,2-dimethoxypropane (48 mL) is added chlorotrimethylsilane (0.38 mL). The reaction mixture is stirred at ambient temperature overnight. The reaction mixture is concentrated under reduced pressure to give the title compound as an oil, (3.8 g, quant.). ¹H NMR (400MHz, CDCl₃): δ 3.86 (s, 3H), 2.72 (d, 2H), 2.16 (m, IH), 0.96 (d, 6H).

References:

ELI LILLY AND COMPANY WO2009/12125, 2009, A1 Location in patent:Page/Page column 19-20

67-56-1 Synthesis

67-56-1
740 suppliers
$7.29/5ml-f

816-66-0 Synthesis

816-66-0
139 suppliers
$14.00/250mg

3682-43-7
62 suppliers
$65.00/100mg

References

816-66-0 Synthesis

816-66-0
139 suppliers
$14.00/250mg

77-76-9
386 suppliers
$9.00/5ml

3682-43-7
62 suppliers
$65.00/100mg