ChemicalBook CAS DataBase List (4-METHYLPYRIDIN-3-YL)METHYLAMINE

(4-METHYLPYRIDIN-3-YL)METHYLAMINE synthesis

3synthesis methods

Product Name:(4-METHYLPYRIDIN-3-YL)METHYLAMINE
CAS Number:1443-42-1
Molecular formula:C7H10N2
Molecular Weight:122.17

7250-52-4
72 suppliers
$32.00/100mg

1443-42-1
58 suppliers
$57.00/100mg

Yield: 95%

Reaction Conditions:

with dimethylsulfide borane complex in tetrahydrofuran at 0 - 20;

Steps:

13
Example 13: Synthesis of 3-aminomethyl-4-methylpyridine EPO 100106] A round bottom flask was charged with 0.45g (3.3OmM) of 4- methylnicotinamide (27). The flask was flushed with argon, and 5OmL of dry THF was added by syringe. The resulting solution was cooled to 0 dg C, and 2.5mL (4.96mM) of a 2M solution of borane-dimethylsulfde complex (in THF) was added. A bubbler was attached, and the solution was allowed to warm to RT overnight. The solution was quenched with MeOH, and dried and evaporated to give 0.38g (95%) of 3-aminomethyl- 4-methylpyridine (28).

References:

PHARMACOPEIA DRUG DISCOVERY, INC. WO2006/108103, 2006, A1 Location in patent:Page/Page column 32-33

5444-01-9
219 suppliers
$16.00/1 g

1443-42-1
58 suppliers
$57.00/100mg

References

3222-50-2
188 suppliers
$12.72/500mgs:

1443-42-1
58 suppliers
$57.00/100mg

References

(4-METHYLPYRIDIN-3-YL)METHYLAMINE Related Search:

4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID HYDRAZIDE 3,4-PYRIDINEDICARBOXIMIDE 2,5-DICHLORO-4,6-DIMETHYLNICOTINAMIDE