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4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID HYDRAZIDE synthesis
- Product Name:4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID HYDRAZIDE
- CAS Number:175204-84-9
- Molecular formula:C7H6F3N3O
- Molecular Weight:205.14
![4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID HYDRAZIDE](/CAS/GIF/175204-84-9.gif)
175204-84-9
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![Pyridine, 3-(5-methyl-1,3,4-oxadiazol-2-yl)-4-(trifluoromethyl)-](/CAS/20210305/GIF/218276-61-0.gif)
218276-61-0
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Yield:-
Reaction Conditions:
with trichlorophosphate in Triethyl orthoacetate;
Steps:
2- Methyl-5-(4-trifluoromethyl-3-pyridyl)-1,3,4-oxadiazole (Table 3, No.549)
2- Methyl-5-(4-trifluoromethyl-3-pyridyl)-1,3,4-oxadiazole (Table 3, No.549) 500 mg of 4-trifluoromethylnicotinic hydrazide were heated under reflux in 3.5 ml of triethyl orthoacetate for 2 hours. The reaction mixture was subsequently concentrated and the residue was carefully admixed with 2 ml of phosphorus oxychloride. The mixture was stirred at room temperature for 1 hour and then poured on ice and extracted with ethyl acetate. Chromatographic purification of the crude product obtained after drying and concentrating gave the desired compound as a yellowish oil. 1H-NMR (CDCl3, 300 MHz): d=2.67 (s, 3H), 7.75 (d, J=5 Hz, 1H), 8.99 (d, J=5 Hz, 1H), 9.34 (s, 1H) ppm.
References:
US2003/162812,2003,A1