ChemicalBook CAS DataBase List 4-N-HEXADECYLOXYANILINE

4-N-HEXADECYLOXYANILINE synthesis

7synthesis methods

Product Name:4-N-HEXADECYLOXYANILINE
CAS Number:7502-06-9
Molecular formula:C22H39NO
Molecular Weight:333.55

102703-33-3 Synthesis

102703-33-3
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7502-06-9
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$48.20/2g

Yield:7502-06-9 81%

Reaction Conditions:

with Graphite;hydrazine hydrate in ethanol; for 48 h;Inert atmosphere;Reflux;

Steps:

4-Hexyloxyphenylamine (3a).

General procedure: A mixture of 2a (40 mmol), hydrazine monohydrate (10 mL,200 mmol), and graphite (24 g, 2 mol) in absolute ethanol (100 mL) was refluxed under N₂ atmosphere for 48 h. The graphite was removed by hot filtration. The filtrate was extracted with dichloromethane. The organic layer was washed with H₂O, dried over anhydrous Na₂SO₄, and evaporated to dryness. The product was dried under vacuum (yield: 91 %).

References:

Huang, Yao-Dong;Tu, Wei;Yuan, Yu-Qin;Fan, Dong-Li [Tetrahedron,2014,vol. 70,# 6,p. 1274 - 1282] Location in patent:supporting information

103-90-2 Synthesis