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P-HEXADECYLOXYNITROBENZENE synthesis

2synthesis methods
-

Yield: 97%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 80; for 5 h;

Steps:

4-Hexyloxy-1-nitrobenzene (2a)
General procedure: Potassium carbonate (12.42 g, 90 mmol) was added to a solution of 4-nitrophenol (8.34 g, 60 mmol) in DMF (100 mL). After stirring at room temperature for 0.5 h, 1-bromohexane (72 mmol) was added slowly and then the reaction mixture was stirredat 80 °C for 5 h. The reaction mixture was cooled to 23 °C and poured intoice-water (400 mL). The resulting precipitate was collected by filtration, and the product was dried under vacuum

References:

Huang, Yao-Dong;Tu, Wei;Yuan, Yu-Qin;Fan, Dong-Li [Tetrahedron,2014,vol. 70,# 6,p. 1274 - 1282] Location in patent:supporting information

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