4-nitro-6-fluoroindazole synthesis

Yield: 43.5%

Reaction Conditions:

with acetic acid;sodium nitrite in water at 0 - 20; for 6 h;

Steps:

3.3 3Synthesis of compound LWQ-145:
Starting material 5b (50 mg, 0.294 mmol) was dissolved in AcOH (10 mL).Add an aqueous solution (3 mL) of sodium nitrite (44.6 mg, 0.588 mmol) at 0 ° C, add rt, stir for 6 h;TLC showed that the starting material was completely reacted, and finally received 18.3 mg of an orange powder, yield: 43.5%.

References:

Xihua University;Yang Lingling;Qian Shan;Li Guobo;Chen Feng;Li Chao;He Yanying;Wang Zhouyu;Lai Peng CN108689937, 2018, A Location in patent:Paragraph 0081; 0082; 0087; 0088