4-OCTYLBENZYLAMINE synthesis

5synthesis methods

Product Name:4-OCTYLBENZYLAMINE
CAS Number:176956-02-8
Molecular formula:C15H25N
Molecular Weight:219.37

88255-11-2
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176956-02-8
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Yield:176956-02-8 100%

Reaction Conditions:

with sodium hexamethyldisilazane;1,1,1,3,3,3-hexamethyl-disilazane in tetrahydrofuran at 20;Inert atmosphere;

Steps:

31.D

To a solution of the product of Step C (0.13 g; 0.459 mmol) in anhydrous hexamethylenedisilazane (HMDSA) 1 M NaHMDSA in THF was added at room temperature under N₂ with stirring. After stirring overnight at room temperature the solvents were removed under reduced pressure and the residue was diluted to 5 ml with MeOH and 1 drop of concentrated HCI was added. This was evaporated under reduced pressure, diluted to 15 ml with Et₂O and washed with 1 N NaOH, brine, dried over anhydrous MgSO₄ and filtered. The filtrate was evaporated under reduced pressure to give the title compound (0.1 g; 100%), as colourless oil, which was used in the next Step without further purification. . ¹ H-NMR (CDCI₃) 0.86 (tr, 3H, J = 7 Hz); 1 .26 (m, 10H); 1 .41 (s, 2H); 1 .58 (m, 2H); 2.57 (tr, 2H, J = 7.9 Hz); 3.82 (s, 2H); 7.13 (d, 2H, J = 8 Hz); 7.2 (d, 2H, J = 8 Hz).

References:

WO2010/42998,2010,A1 Location in patent:Page/Page column 88

3058-39-7 Synthesis