(4-OXO-PIPERIDIN-1-YL)-ACETIC ACID HYDROCHLORIDE synthesis
- Product Name:(4-OXO-PIPERIDIN-1-YL)-ACETIC ACID HYDROCHLORIDE
- CAS Number:218772-96-4
- Molecular formula:C7H11NO3
- Molecular Weight:157.17
41979-39-9
119 suppliers
$15.00/10mg
79-11-8
10 suppliers
$27.00/25g
218772-96-4
36 suppliers
$76.00/100mg
Yield:218772-96-4 92.2%
Reaction Conditions:
with potassium carbonate in water at 60 - 75; for 6 h;Reagent/catalyst;Temperature;
Steps:
1 Example 1: Preparation of 4-piperidone-1-acetic acid (III)
In a 500 ml four-necked flask equipped with a stirring, thermometer, reflux condenser, and constant pressure dropping funnel,Add 60 grams of water, 34.5 grams (0.25 moles) of potassium carbonate,21.8 g (0.23 mol) of chloroacetic acid,Heat, keep between 60-65 ,A solution of 27.1 g (0.2 mole) of piperidin-4-one hydrochloride and 60 g of water was added dropwise,The addition was completed in about 2 hours, and then the reaction was stirred at 70-75 ° C for 4 hours.Cool to 20-25 ° C, 30wt% hydrochloric acid acidification system pH 2.5-3.0, filter, dry,There was obtained 28.95 g of 4-piperidone-1-acetic acid as a white solid,The yield was 92.2%, and the purity of the liquid phase was 99.3%.
References:
CN110483384,2019,A Location in patent:Paragraph 0050-0051; 0066-0067
5292-43-3
445 suppliers
$10.00/5g
40064-34-4
366 suppliers
$10.00/5g
218772-96-4
36 suppliers
$76.00/100mg