ChemicalBook CAS DataBase List PIPERIDIN-1-YL-ACETIC ACID

PIPERIDIN-1-YL-ACETIC ACID synthesis

7synthesis methods

Product Name:PIPERIDIN-1-YL-ACETIC ACID
CAS Number:3235-67-4
Molecular formula:C7H13NO2
Molecular Weight:143.18

23853-10-3
74 suppliers
$23.80/5g

3235-67-4
100 suppliers
$25.00/1g

Yield: 95%

Reaction Conditions:

with hydrogenchloride in water at 95; for 16 h;

Steps:

21.b b) 2-(Piperidin-l-yl) acetic acid
b) 2-(Piperidin-l-yl) acetic acidThe solution of ethyl 2-(piperidin-l-yl)acetate (1 g, 5.84 mmol, 1.0 eq) in 8 N HC1 was stirred at 95 °C for 16 h. The mixture was concentrated and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 95 % yield (0.8 g). LC-MS (ESI): Calculated mass: 143.1 ; Observed mass 144.4 [M+H] ⁺ (rt: 0.21 min).

References:

ORION CORPORATION;LINNANEN, Tero;WOHLFAHRT, Gerd;NANDURI, Srinivas;UJJINAMATADA, Ravi;RAJAGOPALAN, Srinivasan;MUKHERJEE, Subhendu WO2013/53983, 2013, A1 Location in patent:Page/Page column 41