4-P-TOLYLSULFANYL-BUTYRIC ACID synthesis
- Product Name:4-P-TOLYLSULFANYL-BUTYRIC ACID
- CAS Number:18850-48-1
- Molecular formula:C11H14O2S
- Molecular Weight:210.29
20458-90-6
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18850-48-1
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Yield:18850-48-1 99%
Reaction Conditions:
Stage #1: ethyl 4-(p-tolylthio)butanoatewith methanol;sodium hydroxide at 20; for 2 h;
Stage #2: with hydrogenchloride in water;
Steps:
111.2
Step 2 : 2.9 ml_ of 4N sodium hydroxide were added to a solution of 910 mg (3.82 mmol) of ethyl-4-[(4-methylphenyl)thio]butanoate in 5 ml_ of methanol. The mixture was stirred 2 h at room temperature then concentrated in vacuo. Water was added then 6N hydrochloric acid. The formed precipitate was filtered to give 792 mg of 4-[(4- methylphenyl)thio]butanoic acid in 99% yield.
References:
WO2010/66847,2010,A1 Location in patent:Page/Page column 76
