Ethyl 4-(4-methylphenyl)sulfanylbutanoate synthesis

5synthesis methods

Product Name:Ethyl 4-(4-methylphenyl)sulfanylbutanoate
CAS Number:20458-90-6
Molecular formula:C13H18O2S
Molecular Weight:238.3458

2969-81-5 Synthesis

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106-45-6 Synthesis

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Ethyl 4-(4-methylphenyl)sulfanylbutanoate

20458-90-6
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Yield:20458-90-6 95%

Reaction Conditions:

with potassium carbonate in acetonitrile; for 4 h;Reflux;

Steps:

111.1

Step 1 : Anhydrous potassium carbonate (834 mg, 6 mmol) and ethyl 4-bromobutanoate (634 μl_, 4.43 mmol) were added to a solution of 4-methylbenzene thiol (500 mg, 4.02 mmol) in 5 ml_ acetonitrile. The mixture was refluxed 4h then water and ethyl acetate were added after cooling. The mixture was extracted 3 times with ethyl acetate, the combined organic layers were washed with brine, dried with anhydrous MgSO₄, filtered and concentrated in vacuo. The residue was purified by flash chromatography (silica gel) with (cyclohexane / ethyl acetate 98/2) to give 910 mg (95% yield) of ethyl-4-[(4- methylphenyl)thio]butanoate.

References:

WO2010/66847,2010,A1 Location in patent:Page/Page column 76

2969-81-5 Synthesis

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$5.00/1g