ChemicalBook CAS DataBase List 4-Phenylbutyryl chloride

4-Phenylbutyryl chloride synthesis

5synthesis methods

Product Name:4-Phenylbutyryl chloride
CAS Number:18496-54-3
Molecular formula:C10H11ClO
Molecular Weight:182.65

79-37-8
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$17.67/10gm:

1821-12-1 Synthesis

1821-12-1
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$6.00/5g

18496-54-3
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$16.00/100mg

Yield: 98.1%

Reaction Conditions:

in dichloromethane

Steps:

I.B Synthesis of N-[N-(4-phenyl-1-ketobutane)-(L)-prolyl]-2-(S)-[(5-(3-phenylpropane)-1,2,4-oxadiazolyl)-ketomethane]-pyrrolidine (CQ-0006) STR8 A. N-Benzyloxycarbonyl-2-(S)-(2-acetoxyethanamide oxime)-pyrrolidine hydrochloride.
B. 4-Phenylbutanoyl chloride. To a mixture of 4-phenylbutanoic acid (12.0 g, 0.73 mol) in 60 ml of dichloromethane was added oxalyl chloride (12.8 ml, 0.15 mol). This was then stirred at room temperature until gas evolution ceased (2 hrs.). The reaction mixture was then evaporated to yield a yellow oil (13.1 g, 98.1%) which was used without further purification. IR (neat) 1799.6 cm^-1 C=O (acid chloride).

References:

Cortech, Inc. US6159938, 2000, A

1821-12-1 Synthesis

1821-12-1
413 suppliers
$6.00/5g

18496-54-3
73 suppliers
$16.00/100mg

References

1008-76-0 Synthesis