4-Phenylthieno[3,2-c]pyridine synthesis

7synthesis methods

Product Name:4-Phenylthieno[3,2-c]pyridine
CAS Number:81820-65-7
Molecular formula:C13H9NS
Molecular Weight:211.28

Thieno[3,2-c]pyridine, 6,7-dihydro-4-phenyl-

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Yield:81820-65-7 95%

Reaction Conditions:

with palladium 10% on activated carbon in toluene; for 2 h;Reflux;

Steps:

1

10.6g of Compound 2 (50mmol), 10g of palladium on carbon catalyst (palladium 10% on carbon Pd/C), and 50mL of toluene (Toluene) added to the reaction flask. Subsequently, heated to reflux, and reacted for two hours. Subsequently, in order to remove the palladium on carbon catalyst filtration, and the filtrate with ethyl acetate (ethyl acetate, EA), and extracted three times with water, three times and the organic layer was dried and collected by filtration, drained after use roundabout concentrators, and be purified by column chromatography to give compound 3, 95% yield.

References:

TWI526448,2016,B Location in patent:Paragraph 0033