ChemicalBook CAS DataBase List 5-bromo-4-chlorothieno[2,3-d]pyrimidine

5-bromo-4-chlorothieno[2,3-d]pyrimidine synthesis

6synthesis methods

Product Name:5-bromo-4-chlorothieno[2,3-d]pyrimidine
CAS Number:814918-95-1
Molecular formula:C6H2BrClN2S
Molecular Weight:249.52

56844-12-3 Synthesis

56844-12-3
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$11.00/100mg

814918-95-1
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$77.00/100mg

Yield: 67.1%

Reaction Conditions:

with n-butyllithium;diisopropylamine in tetrahydrofuran at -78; for 1 h;Inert atmosphere;

Steps:

[0123] To diisopropylamine (1.028 ml, 7.21 mmol, 1.8 equiv) in 10 mL THF at 0 °C was added n-butyl lithium (3.76 ml, 6.01 mmol, 1.5 equiv). After 1 h, the LDA solution was transferred to a solution of 6-bromo-4-chlorothieno[2,3-d]pyrimidine (1.0 g, 4.01 mmol, 1.0 equiv) in 35 mL THF at -78 °C under nitrogen. The solution stirred for 1 h at -78 °C after which a mixture of 1.25 mL water and 5 mL THF was added slowly. The mixture was then warmed to 0 °C, poured into 60 mL water, and extracted with dichloromethane. The combined organic extracts were then dried over Na2SC> , filtered, and concentrated in vacuo to give a yellow solid which was chromatographed with 20% EtOAc/Hexanes gradient elution to give 5-bromo-4-chlorothieno[2,3-d]pyrimidine (671 mg, 67.1 % yield) as a tan solid. NMR (400 MHz, chloroform- ) δ ppm 8.85 (s, 1 H), 7.64 (s, 1 H).

References:

THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;MARUGAN, Juan, J.;ZHENG, Wei;SOUTHALL, Noel;HUANG, Wenwei;MCCOY, Joshua, G.;TITUS, Steven;PATNAIK, Samarjit WO2012/44993, 2012, A1 Location in patent:Page/Page column 44