4-(Phthalimide)cyclohexanol synthesis
- Product Name:4-(Phthalimide)cyclohexanol
- CAS Number:104618-31-7
- Molecular formula:C14H15NO3
- Molecular Weight:245.27
85-44-9
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104618-31-7
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Yield: 79%
Reaction Conditions:
with pyridinium p-toluenesulfonate in N,N-dimethyl-formamide;toluene for 15 - 17 h;Product distribution / selectivity;Heating / reflux;
Steps:
1.A
A) SOOgms (2.608mole) of Trans-4-aminocyclohexanol was dissolve in 1500mlDimethyl formamide and 1500ml of Toluene. Add 386gms(2.608mole) of Phthalicanhydride and 3gm(0.012mole) pyridinium p-toluene sulphonate. The reaction mixtureis refluxed and remove water continuously from water separator, maintain this conditionfor 15-17 hrs. Evaporate solvent under reduced pressure. Add chloroform (3000ml).Wash organic part with 1000ml of 5%NaHCO3, then wash with 1000ml of brine solution.After concentration of reaction mass, crystallize residue in Isopropyl alcohol.YIELD :503gms(79%)PURITY: 99.66%
References:
ALEMBIC LIMITED WO2006/3677, 2006, A1 Location in patent:Page/Page column 10; 15
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6850-65-3
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104618-31-7
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104618-31-7
54 suppliers
$246.00/250mg