![](/CAS/GIF/104618-31-7.gif)
4-(Phthalimide)cyclohexanol synthesis
- Product Name:4-(Phthalimide)cyclohexanol
- CAS Number:104618-31-7
- Molecular formula:C14H15NO3
- Molecular Weight:245.27
![Phthalic anhydride](/CAS/GIF/85-44-9.gif)
85-44-9
750 suppliers
$9.00/5g
![trans-4-Aminocyclohexanol](/CAS/20180808/GIF/27489-62-9.gif)
27489-62-9
454 suppliers
$5.00/5g
![4-(Phthalimide)cyclohexanol](/CAS/GIF/104618-31-7.gif)
104618-31-7
54 suppliers
$246.00/250mg
Yield: 79%
Reaction Conditions:
with pyridinium p-toluenesulfonate in N,N-dimethyl-formamide;toluene for 15 - 17 h;Product distribution / selectivity;Heating / reflux;
Steps:
1.A
A) SOOgms (2.608mole) of Trans-4-aminocyclohexanol was dissolve in 1500mlDimethyl formamide and 1500ml of Toluene. Add 386gms(2.608mole) of Phthalicanhydride and 3gm(0.012mole) pyridinium p-toluene sulphonate. The reaction mixtureis refluxed and remove water continuously from water separator, maintain this conditionfor 15-17 hrs. Evaporate solvent under reduced pressure. Add chloroform (3000ml).Wash organic part with 1000ml of 5%NaHCO3, then wash with 1000ml of brine solution.After concentration of reaction mass, crystallize residue in Isopropyl alcohol.YIELD :503gms(79%)PURITY: 99.66%
References:
ALEMBIC LIMITED WO2006/3677, 2006, A1 Location in patent:Page/Page column 10; 15
![N-Carbethoxyphthalimide](/CAS/GIF/22509-74-6.gif)
22509-74-6
237 suppliers
$9.00/5g
![4-Aminocyclohexanol](/CAS/GIF/6850-65-3.gif)
6850-65-3
125 suppliers
$31.00/250mg
![4-(Phthalimide)cyclohexanol](/CAS/GIF/104618-31-7.gif)
104618-31-7
54 suppliers
$246.00/250mg
![1H-Isoindol-1-one, 3-hydroxy-](/CAS/20200331/GIF/136918-14-4.gif)
136918-14-4
0 suppliers
inquiry
![4-(Phthalimide)cyclohexanol](/CAS/GIF/104618-31-7.gif)
104618-31-7
54 suppliers
$246.00/250mg