ChemicalBook CAS DataBase List 4-(PIPERIDIN-4-YLOXY)BENZONITRILE

4-(PIPERIDIN-4-YLOXY)BENZONITRILE synthesis

7synthesis methods

Product Name:4-(PIPERIDIN-4-YLOXY)BENZONITRILE
CAS Number:224178-67-0
Molecular formula:C12H14N2O
Molecular Weight:202.25

333954-86-2 Synthesis

tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate

333954-86-2
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224178-67-0
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Yield:224178-67-0 85.2%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 25; for 4 h;

Steps:

4.3 Preparation of 4-(piperidin-4-yloxy)benzonitrile

Tert-butyl-4- (4-cyanophenoxy) piperidine-1-carboxylate(3.5 g, 11.6 mmol) was dissolved in dichloromethane (20 mL)10 mL of trifluoroacetic acid was added,Stirred at 25 ° C for 4 hours,concentrate,The residue was dissolved in dichloromethane (50 mL)A saturated sodium bicarbonate solution (20 mL) was added,Dispensing,The organic phase was dried over anhydrous sodium sulfate,Filter, concentrate,The product (2.0 g, yield 85.2%) was obtained.

References:

CN107226807,2017,A Location in patent:Paragraph 0267-0269