(4-propan-2-yloxyphenyl)-pyridin-3-ylmethanone synthesis
- Product Name:(4-propan-2-yloxyphenyl)-pyridin-3-ylmethanone
- CAS Number:1094639-27-6
- Molecular formula:C15H15NO2
- Molecular Weight:241.2851
6967-88-0
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95091-91-1
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Yield:1094639-27-6 21%
Reaction Conditions:
Stage #1: 1-bromo-4-isopropoxybenzenewith n-butyllithium in diethyl ether;hexane at -78; for 1 h;Inert atmosphere;Cooling with acetone-dry ice;
Stage #2: N-methoxy-N-methylpyridine-3-carboxamide in tetrahydrofuran;diethyl ether;hexane at -78 - 20; for 4.5 h;Inert atmosphere;Cooling with acetone-dry ice;
References:
Keenan, Martine;Abbott, Michael J.;Alexander, Paul W.;Armstrong, Tanya;Best, Wayne M.;Berven, Bradley;Botero, Adriana;Chaplin, Jason H.;Charman, Susan A.;Chatelain, Eric;Von Geldern, Thomas W.;Kerfoot, Maria;Khong, Andrea;Nguyen, Tien;McManus, Joshua D.;Morizzi, Julia;Ryan, Eileen;Scandale, Ivan;Thompson, R. Andrew;Wang, Sen Z.;White, Karen L. [Journal of Medicinal Chemistry,2012,vol. 55,# 9,p. 4189 - 4204] Location in patent:supporting information; experimental part
59-67-6
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10400-19-8
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106-41-2
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$13.00/5g
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