![](/CAS/GIF/74-69-1.gif)
4-Pyrimidinamine, 2-methyl- (9CI) synthesis
- Product Name:4-Pyrimidinamine, 2-methyl- (9CI)
- CAS Number:74-69-1
- Molecular formula:C5H7N3
- Molecular Weight:109.13
![Trimethyl orthoacetate](/CAS/GIF/1445-45-0.gif)
1445-45-0
339 suppliers
$10.00/5mL
![3-Methoxyacrylonitrile](/CAS/GIF/60838-50-8.gif)
60838-50-8
84 suppliers
$60.00/100mg
![4-Pyrimidinamine, 2-methyl- (9CI)](/CAS/GIF/74-69-1.gif)
74-69-1
120 suppliers
$19.00/100mg
Yield: 72%
Reaction Conditions:
with ammonia in methanol at 130; for 8 h;
Steps:
4
Example 4; Synthesis of 2-methyl-4-aminopyrimidine; In a pressure-resistant vessel made of stainless steel having an inner volume of 10 ml were charged 1.0 g (12 mmol) of 3-methoxyacrylonitrile, 3.9 g (32 mmol) of methyl orthoacetate and 4.0 g (56 mmol) of 24% by weight ammonia-methanol solution, and the mixture was reacted under stirring at 130° C. for 8 hours. After completion of the reaction, 20 ml of hexane was added to the reaction mixture, and the mixture was stirred and then filtered to obtain 0.94 g (Isolation yield: 72%) of 2-methyl-4-aminopyrimidine as yellow crystals. Physical properties of the 2-methyl-4-aminopyrimidine were as follows. 1H-NMR (DMSO-d6, δ (ppm)); 2.29 (3H, s), 6.22 (1H, dd, J=5.9, 0.5 Hz), 6.69 (2H, brs), 7.94 (1H, d, J=5.9 Hz) CI-MS (m/e); 109 (M+1)
References:
Nishino, Shigeyoshi;Hirotsu, Kenji;Shima, Hidetaka;Harada, Takashi US2008/45712, 2008, A1 Location in patent:Page/Page column 3-4
![4-Amino-6-chloro-2-methylpyrimidine](/CAS/GIF/1749-68-4.gif)
1749-68-4
143 suppliers
$8.00/1g
![4-Pyrimidinamine, 2-methyl- (9CI)](/CAS/GIF/74-69-1.gif)
74-69-1
120 suppliers
$19.00/100mg
![4-CHLORO-2-METHYLPYRIMIDINE](/CAS/GIF/4994-86-9.gif)
4994-86-9
201 suppliers
$16.00/1g
![4-Pyrimidinamine, 2-methyl- (9CI)](/CAS/GIF/74-69-1.gif)
74-69-1
120 suppliers
$19.00/100mg
![4,6-Dichloro-2-methylpyrimidine](/CAS/GIF/1780-26-3.gif)
1780-26-3
473 suppliers
$10.00/10g
![4-Pyrimidinamine, 2-methyl- (9CI)](/CAS/GIF/74-69-1.gif)
74-69-1
120 suppliers
$19.00/100mg
![4,6-Dihydroxy-2-methylpyrimidine](/CAS/GIF/40497-30-1.gif)
40497-30-1
328 suppliers
$14.00/5g
![4-Pyrimidinamine, 2-methyl- (9CI)](/CAS/GIF/74-69-1.gif)
74-69-1
120 suppliers
$19.00/100mg