ChemicalBook CAS DataBase List 4-tert-Butyl-2-chlorophenol

4-tert-Butyl-2-chlorophenol synthesis

10synthesis methods

Product Name:4-tert-Butyl-2-chlorophenol
CAS Number:98-28-2
Molecular formula:C10H13ClO
Molecular Weight:184.66

98-54-4
413 suppliers
$16.00/25g

98-28-2
66 suppliers
$49.00/100g

Yield:98-28-2 95%

Reaction Conditions:

with SO₂Cl₂ in methanol;dichloromethane;water;

Steps:

7 4-tert-butyl-2-chloro-phenol

Example 7 4-tert-butyl-2-chloro-phenol To a solution of 4-tert-butyl-phenol (40.0 g, 0.27 mol) and SO₂Cl₂ (37.5 g, 0.28 mol) in CH₂Cl₂ was added MeOH (9.0 g, 0.28 mol) at 0° C. After addition was complete, the mixture was stirred overnight at room temperature and then water (200 mL) was added. The resulting solution was extracted with ethyl acetate. The combined organic layers were dried over anhydrous Na₂SO₄, filtered and concentrated under vacuum. The residue was purified by column chromatography (Pet. Ether/EtOAc, 50:1) to give 4-tert-butyl-2-chloro-phenol (47.0 g, 95%).

References:

US2011/98311,2011,A1 US2012/309758,2012,A1

98-54-4
413 suppliers
$16.00/25g

98-28-2
66 suppliers
$49.00/100g

34593-75-4 Synthesis