Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 4-tert-Butyl-2-chlorophenol
98-28-2

4-tert-Butyl-2-chlorophenol synthesis

10synthesis methods
-

Yield:98-28-2 95%

Reaction Conditions:

with SO2Cl2 in methanol;dichloromethane;water;

Steps:

7 4-tert-butyl-2-chloro-phenol

Example 7 4-tert-butyl-2-chloro-phenol To a solution of 4-tert-butyl-phenol (40.0 g, 0.27 mol) and SO2Cl2 (37.5 g, 0.28 mol) in CH2Cl2 was added MeOH (9.0 g, 0.28 mol) at 0° C. After addition was complete, the mixture was stirred overnight at room temperature and then water (200 mL) was added. The resulting solution was extracted with ethyl acetate. The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated under vacuum. The residue was purified by column chromatography (Pet. Ether/EtOAc, 50:1) to give 4-tert-butyl-2-chloro-phenol (47.0 g, 95%).

References:

US2011/98311,2011,A1 US2012/309758,2012,A1

4-tert-Butyl-2-chlorophenol Related Search: