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4-TERT-BUTYLBENZYLISOCYANIDE synthesis

4synthesis methods
7677-24-9 Synthesis
Trimethylsilyl cyanide

7677-24-9
370 suppliers
$19.00/5g

18880-00-7 Synthesis
4-tert-Butylbenzyl bromide

18880-00-7
200 suppliers
$9.00/5g

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Yield:728919-99-1 92%

Reaction Conditions:

Stage #1: trimethylsilyl cyanide;1-(bromomethyl)-4-(1,1-dimethylethyl)benzenewith silver perchlorate in dichloromethane at 20; for 1 h;
Stage #2: with sodium hydrogencarbonate in dichloromethane; for 0.166667 h;

References:

Kitano, Yoshikazu;Manoda, Tetsuya;Miura, Teppei;Chiba, Kazuhiro;Tada, Masahiro [Synthesis,2006,# 3,p. 405 - 410]