ChemicalBook CAS DataBase List 2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)-3-((3,4-dimethoxyphenyl )methyl)dihydro-, (3R-trans)-

2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)-3-((3,4-dimethoxyphenyl )methyl)dihydro-, (3R-trans)- synthesis

7synthesis methods

Product Name:2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)-3-((3,4-dimethoxyphenyl )methyl)dihydro-, (3R-trans)-
CAS Number:40456-51-7
Molecular formula:C21H22O6
Molecular Weight:370.4

21852-32-4
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2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)dihydro-, (4R)-

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2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)-3-((3,4-dimethoxyphenyl )methyl)dihydro-, (3R-trans)-

40456-51-7
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Yield:40456-51-7 99%

Reaction Conditions:

Stage #1: (R)-(+)-3-piperonyl-4-butanolidewith N,N,N,N,N,N-hexamethylphosphoric triamide;n-butyllithium;2,2-diphenylacetic acid;diisopropylamine in tetrahydrofuran;hexane at -78; for 1 h;
Stage #2: 4-bromomethyl-1,2-dimethoxybenzene in tetrahydrofuran;hexane at -50 - -20; for 2 h;stereoselective reaction;

References:

Welin, Eric R.;Warkentin, Alexander A.;Conrad, Jay C.;MacMillan, David W. C. [Angewandte Chemie - International Edition,2015,vol. 54,# 33,p. 9668 - 9672][Angew. Chem.,2015,vol. 127,# 33,p. 9804 - 9808,5] Location in patent:supporting information

51842-87-6
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References

2107-70-2 Synthesis

2107-70-2
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Benzenepropanoic acid, 3,4-dimethoxy-, 1,1-dimethylethyl ester

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40456-51-7
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75590-33-9
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40456-51-7
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