2-[3-(pyridin-2-ylsulfanyl)propyl]-2,3-dihydro-1H-isoindole-1,3-dione synthesis

Yield:443120-58-9 99%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 90; for 6 h;Inert atmosphere;

Steps:

4.2. General procedure for compounds 7a-r

General procerure: To a suspension of mercaptan substituent heterocyclic in DMF, one equivalent of N-(3-bromopropyl) phthalimide and K₂CO₃ (1 equivalent) were added. The reaction was stirred for 6 h at 90 °C before cooled to room temperature. After evaporation of the DMF under vacuum, the residue was diluted with methylene chloride, washed with water and brine, and dried over MgSO₄. After evaporation of the solution, the crude products were purified by column chromatography eluting with 2.5:1 petroleum ether/acetone to afford the desired products as yellow or white solid.

References:

Chen, Xiao-Zhuo;Xu, Peng;Liu, Lu;Zheng, Dan;Lei, Ping-Sheng [European Journal of Medicinal Chemistry,2011,vol. 46,# 1,p. 208 - 217] Location in patent:experimental part