3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehyde synthesis

2synthesis methods

Product Name:3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehyde
CAS Number:443956-16-9
Molecular formula:C8H6N2O2S
Molecular Weight:194.21

6-(hydroxymethyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one

443956-15-8
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3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehyde

443956-16-9
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Yield:443956-16-9 100%

Reaction Conditions:

with manganese(IV) oxide in tetrahydrofuran;dichloromethane at 20; for 37 h;

Steps:

2.d

A solution of 6-hydroxymethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1 ,4]thiazine (330 mg) in dichloromethane (30 mL)/THF (30 mL) was treated with manganese dioxide (730 mg) and stirred at room temperature. Further manganese dioxide was added after 1 h (730 mg) and 16 h (300 mg). After a total of 20 h the mixture was filtered through kieselguhr and the filtrate evaporated. The product was triturated with EtOAc/hexane EPO (1 :1) and collected to give a solid (180mg): LC/MS (APCI^") m/z 195 ([M-H]-, 95%), 165 (100%).

References:

WO2006/81178,2006,A2 Location in patent:Page/Page column 21-22

443956-13-6 Synthesis

Methyl3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate

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443956-16-9
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References