![](/CAS/GIF/446292-07-5.gif)
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione synthesis
- Product Name:2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
- CAS Number:446292-07-5
- Molecular formula:C21H21N3O5
- Molecular Weight:395.41
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161596-47-0
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$6.00/5g
![4-(4-AMINOPHENYL)MORPHOLIN-3-ONE](/CAS/GIF/438056-69-0.gif)
438056-69-0
601 suppliers
$10.00/5g
![2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione](/CAS/GIF/446292-07-5.gif)
446292-07-5
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Yield:446292-07-5 95%
Reaction Conditions:
in ethanol;water at 20; for 15 h;Solvent;Temperature;
Steps:
4-9 Example 4: Preparation of Compound C
Add 96g Compound A (made in accordance with the example of Patent Document CN100430384C, HPLC purity 96.0%), 960mL 95% (v/v) ethanol aqueous solution and 120g Compound B (made according to the method of Example 1) to the reaction flask, and reflux to react 15 hours, cooled to 20 °C, filtered, washed with 200 mL of 95% ethanol aqueous solution, and dried under vacuum at 70 ° C for 5 hours to obtain 188 g of compound C, off-white solid, molar yield: 95%, HPLC purity: 95.0%, impurity E content: 2.8 %, Ee value: 96.2%.
References:
Zhejiang Haixiang Pharmaceutical Co., Ltd.;Shanghai Haixiang Pharmaceutical Co., Ltd.;Tang Fanghui;Liang Chao;Ni Zhizhong;Zhao Fulu;Li Hongming CN111039937, 2020, A Location in patent:Paragraph 0066-0082
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1074-82-4
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$5.00/25g
![2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione](/CAS/GIF/446292-07-5.gif)
446292-07-5
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![N-(2,3-EPOXYPROPYL)PHTHALIMIDE](/CAS/GIF/5455-98-1.gif)
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![4-(4-AMINOPHENYL)MORPHOLIN-3-ONE](/CAS/GIF/438056-69-0.gif)
438056-69-0
601 suppliers
$10.00/5g
![2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione](/CAS/GIF/446292-07-5.gif)
446292-07-5
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![2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione](/CAS/GIF/446292-07-5.gif)
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![2-Anilinoethanol](/CAS/GIF/122-98-5.gif)
122-98-5
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![2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione](/CAS/GIF/446292-07-5.gif)
446292-07-5
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