ChemicalBook >> CAS DataBase List >>2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
- CAS No.
- 446292-07-5
- Chemical Name:
- 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
- Synonyms
- C21H2IN3Os .;2-Amino-12-picoline;Rivaroxaban Impurity 50;Rivaroxaban interMediate B;Intermediate of Rivaroxaban 4;-2-(2-Hydroxy-3-((4-(3-oxomorpholino);Rivaroxaban Phthalimido Descarbonyl Impurity;2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}pr...;4-[((2R)-Hydroxy-3-phthaliMido)propylaMine]phenyl-3-Morpholinone;2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-
- CBNumber:
- CB12468597
- Molecular Formula:
- C21H21N3O5
- Molecular Weight:
- 395.41
- MDL Number:
- MFCD11977664
- MOL File:
- 446292-07-5.mol
Last updated:2024-06-12 17:09:27
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Properties
Melting point | 208-211°C |
---|---|
Boiling point | 734.9±60.0 °C(Predicted) |
Density | 1.421 |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
pka | 13.91±0.20(Predicted) |
form | Solid |
color | White to Off-White |
Water Solubility | 37mg/L at 20℃ |
LogP | 0.6 at 25℃ |
CAS DataBase Reference | 446292-07-5 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H312-H332 |
Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501 |
HS Code | 2922498590 |
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | H948920 | 4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone | 446292-07-5 | 25mg | $385 | 2021-12-16 | Buy |
TRC | H948920 | 4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone | 446292-07-5 | 50mg | $725 | 2021-12-16 | Buy |
AK Scientific | Z3537 | 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-mopholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2h)-dione | 446292-07-5 | 100mg | $82 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | CCH0032813 | (R)-2-(2-HYDROXY-3-((4-(3-OXOMORPHOLINO)PHENYL)AMINO)PROPYL)ISOINDOLINE-1,3-DIONE 95.00% | 446292-07-5 | 1G | $402.15 | 2021-12-16 | Buy |
AK Scientific | Z3537 | 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-mopholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2h)-dione | 446292-07-5 | 1g | $139 | 2021-12-16 | Buy |
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Rivaroxaban intermediate.
Uses
4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone is a Rivaroxaban (R538000(P)) intermediate. Rivaroxaban is a novel antithrombotic agent. It is also a highly potent and selective, direct FXa inhibitor.
Flammability and Explosibility
Non flammable
![161596-47-0](/CAS/GIF/161596-47-0.gif)
![438056-69-0](/CAS/GIF/438056-69-0.gif)
![446292-07-5](/CAS/GIF/446292-07-5.gif)
Synthesis of 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione from (S)-(+)-Glycidyl Phthalimide and 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Preparation Products And Raw materials
Global( 243)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29892 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 906 | 58 |
Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +8615064153060 | sales01@jndxj.com | China | 291 | 58 |
View Lastest Price from 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-19 | 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
446292-07-5
|
US $100.00-2500.00 / KG | 1KG | 99% | 2MT per month | Anhui Dexinjia Biopharm Co., Ltd | |
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2023-05-26 | 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-1H-ISOINDOLE- 1,3(2H)-DIONE
446292-07-5
|
US $0.00-0.00 / Kg | 1Kg | 99% | 1-10000kgs | Changzhou Rokechem Technology Co., Ltd. | |
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2022-10-07 | 1H-isoindole-1,3(2H) -Dione, 2-[(2R) -2-Hydroxy-3 -[[4-(3-OXO-4-morpholinyl)PHENYL]AMINO]PROPYL]-
446292-07-5
|
US $30.00-28.00 / Kg | 1Kg | 99.0% up | 50 tons per month | Xinxiang Hongqi District Houyuan Trading Co.,Ltd |
-
- 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
446292-07-5
- US $100.00-2500.00 / KG
- 99%
- Anhui Dexinjia Biopharm Co., Ltd
-
- 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-1H-ISOINDOLE- 1,3(2H)-DIONE
446292-07-5
- US $0.00-0.00 / Kg
- 99%
- Changzhou Rokechem Technology Co., Ltd.
-
- 1H-isoindole-1,3(2H) -Dione, 2-[(2R) -2-Hydroxy-3 -[[4-(3-OXO-4-morpholinyl)PHENYL]AMINO]PROPYL]-
446292-07-5
- US $30.00-28.00 / Kg
- 99.0% up
- Xinxiang Hongqi District Houyuan Trading Co.,Ltd
446292-07-5(2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione)Related Search:
1,2-BenzenedicarboxaMide, N1,N2-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-
2-QuinazolineMethanol, 4-Methyl-
Rivaroxaban Impurity 34
(R)-N-Glycidylphthalimide
4,5-DICHLOROTHIOPHENE-2-CARBOXYLIC ACID
2-Thiophenecarboxylic acid
1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-
Rivaroxaban
POLYSTYRENE IODOSOACETATE
1,2-Cyclohexanedione
1of4
1H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-
4-[((2R)-Hydroxy-3-phthaliMido)propylaMine]phenyl-3-Morpholinone
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2H)-dione
2-[(2R)-2-hydroxy-3-{[4-(3-oxoMorpholin-4-yl)phenyl]aMino}p
ropyl]-1H-isoindole-1,3(2H)-dione
(R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)-amino)propyl)isoindoline-1,3-dione
Rivaroxaban interMediate B
2-[(2R)-2-hydroxy-3-[4-(3-oxomorpholin-4-yl)anilino]propyl]isoindole-1,3-dione
Rivaroxaban Phthalimido Descarbonyl Impurity
2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-
-2-(2-Hydroxy-3-((4-(3-oxomorpholino)
Rivaroxaban Impurity 10/4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
Rivaroxaban Impurity 50
H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-
R –(2-Hydroxy-3-((4-(3-Oxo morpholino) Phenyl) Amino) Propyl) Isoindoline-1,3-dione
2-Amino-12-picoline
2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}pr...
TIANFUCHEM--446292-07-5---1H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-
C21H2IN3Os .
Intermediate of Rivaroxaban 4
446292-07-5
Chiral Reagents
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals
Intermediate of Rivaroxaban