1-(Bromomethyl)-2-fluoro-3-iodobenzene, alpha-Bromo-2-fluoro-3-iodotoluene synthesis
- Product Name:1-(Bromomethyl)-2-fluoro-3-iodobenzene, alpha-Bromo-2-fluoro-3-iodotoluene
- CAS Number:447463-83-4
- Molecular formula:C7H5BrFI
- Molecular Weight:314.92
307975-02-6
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447463-83-4
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Yield:447463-83-4 3.7 g
Reaction Conditions:
with carbon tetrabromide;triphenylphosphine in tetrahydrofuran at 0 - 20; for 4 h;
Steps:
73 Synthesis of compound M-2
Take compound M-1 (1g)And triphenylphosphine (7g) dissolved in anhydrous tetrahydrofuran (40mL),Slowly add carbon tetrabromide (8.9g) under ice bath,The reaction was stopped after reacting at room temperature for about 4 hours.The solvent was distilled off under reduced pressure, diluted with dichloromethane (10 mL) and filtered through diatomaceous earth.The mother liquor is purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=2:1),A pale yellow solid compound M-2 (3.7 g) was obtained.
References:
CN111909108,2020,A Location in patent:Paragraph 0694; 0698; 0703-0704
348-52-7
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447463-83-4
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447464-03-1
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447463-83-4
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