ChemicalBook CAS DataBase List 1-tert-butyl 2-Methyl 2-Methylpiperidine-1,2-dicarboxylate

1-tert-butyl 2-Methyl 2-Methylpiperidine-1,2-dicarboxylate synthesis

5synthesis methods

Product Name:1-tert-butyl 2-Methyl 2-Methylpiperidine-1,2-dicarboxylate
CAS Number:470668-97-4
Molecular formula:C13H23NO4
Molecular Weight:257.33

132910-79-3
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1-tert-butyl 2-Methyl 2-Methylpiperidine-1,2-dicarboxylate

470668-97-4
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$58.00/1g

Yield:470668-97-4 95 %

Reaction Conditions:

with lithium diisopropyl amide in tetrahydrofuran at 0;

Steps:

Methyl N-Boc-2-methylpiperidine-2-carboxylate

N-BOC-piperidine-2-carboxylic acid methyl ester (10.0 g, 41.15 mmol) and iodomethane (16.2 g, 123.4 mmol) were added to tetrahydrofuran (60 mL),After cooling to 0°C, a tetrahydrofuran solution of lithium diisopropylamide (2M, 61.7 mL, 123.4 mmol) was added dropwise.After stirring for 3 hours, the reaction solution was poured into saturated ammonium chloride solution, extracted with ethyl acetate, the organic phase was concentrated, and purified by column chromatography (petroleum ether/ethyl acetate=20/1) to obtain the title compound (10.0 g, 95 %)

References:

WO2022/233302,2022,A1 Location in patent:Page/Page column 32