Phospholane, 1-hydroxy-2,5-diphenyl-, 1-oxide, (2S,5S)- synthesis

6synthesis methods

Product Name:Phospholane, 1-hydroxy-2,5-diphenyl-, 1-oxide, (2S,5S)-
CAS Number:474049-73-5
Molecular formula:C16H17O2P
Molecular Weight:272.28

1-Phospholanamine, N,N-diethyl-2,5-diphenyl-, 1-oxide, (2R,5R)-

1428255-91-7
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226393-33-5 Synthesis

Phospholane, 1-hydroxy-2,5-diphenyl-, 1-oxide, (2R,5R)-

226393-33-5
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Phospholane, 1-hydroxy-2,5-diphenyl-, 1-oxide, (2S,5S)-

474049-73-5
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Yield:81 % ee

Reaction Conditions:

with hydrogenchloride;water in methanol at 60; for 16 h;Overall yield = 75 %; Overall yield = 0.225 g;

References:

Hintermann, Lukas;Schmitz, Marco;Maltsev, Olegv.;Naumov, Pance [Synthesis,2013,vol. 45,# 3,art. no. SS-2012-T0745-FA,p. 308 - 325] Location in patent:supporting information

1H-Phosphol-1-amine, 2,5-dihydro-N,N-dimethyl-2,5-diphenyl-, 1-oxide, (1α,2β,5β)-

226393-31-3
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474049-73-5
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1H-Phosphol-1-amine, 2,5-dihydro-N,N-dimethyl-2,5-diphenyl-, 1-oxide, (2R,5S)-rel-

949575-77-3
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474049-73-5
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References

1-Phospholanamine, N,N-dimethyl-2,5-diphenyl-, 1-oxide, (1α,2β,5β)-

226393-36-8
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474049-73-5
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References

1H-Phosphol-1-amine, N,N-diethyl-2,3-dihydro-2,5-diphenyl-, 1-oxide, (1R,2R)-

1159633-63-2
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226393-33-5 Synthesis

226393-33-5
10 suppliers
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474049-73-5
17 suppliers
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References