METHYL ESTER, 2-AMINO-4,5-BIS(2-METHOXYETHOXY)BENZOIC ACID synthesis

9synthesis methods

Product Name:METHYL ESTER, 2-AMINO-4,5-BIS(2-METHOXYETHOXY)BENZOIC ACID
CAS Number:476168-17-9
Molecular formula:C14H21NO6
Molecular Weight:299.32

METHYL ESTER, 4,5-BIS(2-METHOXYETHOXY)-2-NITROBENZOIC ACID

501684-22-6
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METHYL ESTER, 2-AMINO-4,5-BIS(2-METHOXYETHOXY)BENZOIC ACID

476168-17-9
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inquiry

Yield:476168-17-9 202.4 g

Reaction Conditions:

with hydrogenchloride;iron;ammonium chloride in ethanol;water at 80; for 15 h;Inert atmosphere;Concentration;

Steps:

1.6 6

in 3000 ml to three-opening bottle 2000ml90% ethanol, 205g (1eq) ELTE, 104.6g (3eq) iron powder and 10.25g ammonium chloride, the nitrogen 3 times, stirring next adds by drops 10.25g concentrated hydrochloric acid; under the protection of nitrogen, the temperature is increased to 80 °C reflux reaction 15h; cooling to 40 °C, pad of diatomaceous earth filtration, the filter cake is washed with anhydrous ethanol washing; filtrate 50 °C concentrated under reduced pressure to dry, shall be 202.4g ELTF oil, yield > 100% (solvent not concentrated dry).

References:

CN105566233,2016,A Location in patent:Paragraph 0015; 0047