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1-[2-(1H-INDOL-3-YL)-ETHYL]-2-METHYL-5-OXO-4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER
1-[2-(1H-INDOL-3-YL)-ETHYL]-2-METHYL-5-OXO-4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER synthesis
1synthesis methods
- Product Name:1-[2-(1H-INDOL-3-YL)-ETHYL]-2-METHYL-5-OXO-4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER
- CAS Number:477871-83-3
- Molecular formula:C17H18N2O3
- Molecular Weight:298.34
Yield:477871-83-3 43%
Reaction Conditions:
Stage #1: tryptamine;4,5-Dihydro-2-methyl-5-oxofuran-3-carbonsaeuremethylesterwith (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid in toluene at 110; for 0.833333 h;
Stage #2: with triethylamine in tetrahydrofuran;
References:
Muratore, Michael E.;Holloway, Chloe A.;Pilling, Adam W.;Storer, R. Ian;Trevitt, Graham;Dixon, Darren J. [Journal of the American Chemical Society,2009,vol. 131,# 31,p. 10796 - 10797] Location in patent:supporting information; experimental part