6-HYDROXY-1-ISOPROPYL-4-(4-ISOPROPYLPHENYL)-1H-QUINAZOLIN-2-ONE synthesis

Yield:478963-71-2 76%

Reaction Conditions:

with boron tribromide in dichloromethane at 20;

References:

Widler, Leo;Altmann, Eva;Beerli, René;Breitenstein, Werner;Bouhelal, Rochdi;Buhl, Thomas;Gamse, Rainer;Gerspacher, Marc;Halleux, Christine;John, Markus R.;Lehmann, Hansjoerg;Kalb, Oskar;Kneissel, Michaela;Missbach, Martin;Müller, Irene R.;Reidemeister, Sibylle;Renaud, Johanne;Taillardat, Agnes;Tommasi, Ruben;Weiler, Sven;Wolf, Romain M.;Seuwen, Klaus [Journal of Medicinal Chemistry,2010,vol. 53,# 5,p. 2250 - 2263] Location in patent:scheme or table