7-Fluoroisoquinoline-3-carboxylic acid hydrochloride synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride in water; for 2.5 h;Heating / reflux;

Steps:

304

The compound obtained in Referential Example 303 (1.45 g) was dissolved in concentrated HCl (18 mL), and the solution was heated under reflux for 2.5 hours. The reaction mixture was cooled, and the precipitated crystals were collected by filtration. The crystals were washed with water, and was dried, to thereby give the title compound (0.46 g).1H-NMR(DMSO-d6) δ:7.90-8.00(1H, m), 8.15-8.25(1H, m), 8.40-8.50(1H, m), 8.82(1H, s), 9.55(1H, s). MS(FAB)m/z:192(M+H)+.

References:

EP1577301,2005,A1 Location in patent:Page/Page column 222