TERT-BUTYL 3-((METHOXYCARBONYL)METHYL) AZETIDINE-1-CARBOXYLATE synthesis

Yield:-

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20;

Steps:

20.1
;A mixture of [1-(tert-butoxycarbonyl)azetidin-3-yl]acetic acid (2 g, 9.24 mmol), potassium carbonate (1.54 g, 11.1 mmol) and methyl iodide (2.89 mL, 46.5 mmol) in N,N-dimethylformamide (30 mL) was stirred at room temperature under nitrogen overnight. The reaction mixture was diluted with water and extracted with dichloromethane (x2). The combined organic layers were washed with saturated sodium hydrogencarbonate solution, dried over MgSO₄ and concentrated in vacuo. The residue was dissolved in dichloromethane (5 mL) and trifluoroacetic acid (5 mL) added. The reaction was stirred at room temperature for 30 minutes. The solvent was removed in vacuo. The residue was dissolved in N,N-dimethylformamide (30 mL). 2,4-Difluorophenethyl bromide (2.26 g, 10.2 mmol) and potassium carbonate (5.14 g, 37.2 mmol) were added and the reaction heated at 60° C. overnight. The cooled reaction mixture was diluted with water and extracted with dichloromethane (x3). The combined organic layers were washed with brine, dried over MgSO₄ and concentrated in vacuo. The residue was purified by flash column chromatography on silica, eluding with 5% methanol/dichloromethane, to give methyl{1-[2-(2,4-difluorophenyl)ethyl]azetidin-3-yl}acetate (1.3 g, 52%). ¹H NMR (360 MHz, CDCl₃) δ 7.15-7.09 (1H, m), 6.79-6.71 (2H, m), 3.64 (3H, s), 3.48-3.44 (2H, m), 2.87-2.75 (3H, m), 2.60 (4H, s), 2.57 (2H, d, J=7.1 Hz); m/z (ES⁺) 270 (M+H)⁺.

References:

Chambers, Mark Stuart;Curtis, Neil Roy;MacLeod, Angus Murray;Maxey, Robert James;Szekeres, Helen Jane US2005/101586, 2005, A1 Location in patent:Page/Page column 11-12