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5-(4-CHLORO-PHENYL)-[1,3,4]OXADIAZOL-2-YLSULFANYL]-ACETIC ACID synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: hydrazine hydrate / ethanol / Reflux
2: potassium hydroxide / ethanol / 20 h / Reflux
3: potassium hydroxide / water; ethanol / 5 h / Reflux

References:

Wang, Zi-Zhen;Sun, Wen-Xue;Wang, Xue;Zhang, Ya-Han;Qiu, Han-Yue;Qi, Jin-Liang;Pang, Yan-Jun;Lu, Gui-Hua;Wang, Xiao-Ming;Yu, Fu-Gen;Yang, Yong-Hua [Chemical Biology and Drug Design,2017,vol. 90,# 2,p. 236 - 243]