5-[(1-Indolyl)Methyl]-3-Methylisoxazole synthesis
- Product Name:5-[(1-Indolyl)Methyl]-3-Methylisoxazole
- CAS Number:528593-71-7
- Molecular formula:C13H12N2O
- Molecular Weight:212.25
120-72-9
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Yield:528593-71-7 76%
Reaction Conditions:
Stage #1: indolewith potassium tert-butylate in tetrahydrofuran at 0; for 0.5 h;
Stage #2: 5-chloromethyl-3-methylisoxazole in tetrahydrofuran at 20; for 4 h;
References:
Li, Wen-Tai;Hwang, Der-Ren;Chen, Ching-Ping;Shen, Chien-Wei;Huang, Chen-Long;Chen, Tung-Wei;Lin, Chi-Hung;Chang, Yee-Ling;Chang, Ying-Ying;Lo, Yue-Kan;Tseng, Huan-Yi;Lin, Chu-Chung;Song, Jeng-Shin;Chen, Hua-Chien;Chen, Shu-Jen;Wu, Se-Hui;Chen, Chiung-Tong [Journal of Medicinal Chemistry,2003,vol. 46,# 9,p. 1706 - 1715]