5-(4-bromophenyl)picolinonitrile synthesis
1synthesis methods
- Product Name:5-(4-bromophenyl)picolinonitrile
- CAS Number:951657-98-0
- Molecular formula:C12H7BrN2
- Molecular Weight:259.1
Yield:951657-98-0 82%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);sodium carbonate in methanol;water;toluene at 80;Inert atmosphere;Suzuki coupling;
References:
Hu, Laixing;Arafa, Reem K.;Ismail, Mohamed A.;Patel, Alpa;Munde, Manoj;Wilson, W. David;Wenzler, Tanja;Brun, Reto;Boykin, David W. [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 18,p. 6651 - 6658] Location in patent:experimental part