5-(4-Nitrophenyl)-4H-1,2,4-triazol-3-amine synthesis

6synthesis methods

Product Name:5-(4-Nitrophenyl)-4H-1,2,4-triazol-3-amine
CAS Number:59301-21-2
Molecular formula:C8H7N5O2
Molecular Weight:205.17

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5-(4-Nitrophenyl)-4H-1,2,4-triazol-3-amine

59301-21-2
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Yield:59301-21-2 91%

Reaction Conditions:

with potassium carbonate;dimethyl sulfate in water at 50; for 15 h;Green chemistry;

Steps:

General procedure for the preparation of 1,2,4-triazol-5(3)-amines 4a-j

General procedure: A suspension of thiourea (1) (0.076 g, 1 mmol), hydrazides 3a-j (1 mmol), dimethyl sulfate (2) (0.063 g, 0.5 mmol) and potassium carbonate (0.069 g, 0.5 mmol) in 4 mL water was heated at 50 °C for 15-20 h. The reaction progress was checked with TLC. The mixture was cooled in an ice bath in order to increase in total precipitation. The solid was fltered of, washed with cold water and ethanol, and dried in an oven at 60 °C without need for further purifcation.

References:

Beyzaei, Hamid;Khosravi, Zahra;Aryan, Reza;Ghasemi, Behzad [Journal of the Iranian Chemical Society,2019,vol. 16,# 12,p. 2565 - 2573]