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ChemicalBook CAS DataBase List 5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLIC&

5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLIC& synthesis

5synthesis methods
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Yield:80387-79-7 98%

Reaction Conditions:

Stage #1: methyl 5-(4-nitrophenyl)thiophene-2-carboxylatewith sodium hydroxide in tetrahydrofuran;ethanol; for 5 h;Reflux;
Stage #2: with hydrogenchloride in water at 0;

References:

Mori, Matteo;Stelitano, Giovanni;Chiarelli, Laurent R.;Cazzaniga, Giulia;Gelain, Arianna;Barlocco, Daniela;Pini, Elena;Meneghetti, Fiorella;Villa, Stefania [Pharmaceuticals,2021,vol. 14,# 2,p. 1 - 17]

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