ChemicalBook CAS DataBase List 5 5-DIMETHYL-1 3 2-DIOXAPHOSPHORINAN-2-&

5 5-DIMETHYL-1 3 2-DIOXAPHOSPHORINAN-2-& synthesis

11synthesis methods

Product Name:5 5-DIMETHYL-1 3 2-DIOXAPHOSPHORINAN-2-&
CAS Number:4090-60-2
Molecular formula:C5H11O3P
Molecular Weight:150.11

126-30-7 Synthesis

126-30-7
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5 5-DIMETHYL-1 3 2-DIOXAPHOSPHORINAN-2-&

4090-60-2
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$91.40/5g

Yield:4090-60-2 100%

Reaction Conditions:

with phosphonic Acid in toluene; for 18 h;Dean-Stark;Reflux;

Steps:

EXAMPLE

[0054] To a solution of phosphorous acid H3P03 (50%, 114.8 g, 700 mmol) in toluene (1.4 L) neopentyiglycol (73.64 g, 700 mmol) was added. The reflux system was equipped with a Dean-Stark trap prefihled with toluene. The reaction mixture was refluxed for 1 8b. The reaction mixture was allowed to cooi down to room temperature. The solution was concentrated under high vacuum to give the expected cyclic neopentyiglycol phosphonate ester at 100% yield. Phosphorus NMR 31P showed a single peak at 2.99 ppm (d).

References:

WO2015/153094,2015,A1 Location in patent:Paragraph 0054