5,5-dimethyl-2-propan-2-yl-2H-1,3-thiazole synthesis
- Product Name:5,5-dimethyl-2-propan-2-yl-2H-1,3-thiazole
- CAS Number:32899-85-7
- Molecular formula:C8H15NS
- Molecular Weight:157.28
78-84-2
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Yield:32899-85-7 87.2%
Reaction Conditions:
with ammonium hydroxide;sulfur;triethylamine at 55 - 90; for 2 h;Large scale;
Steps:
The sulfur powder 720g,Isobutyraldehyde 3250g,Triethylamine 100g was added to a 10L glass reactor,Warm to 55 appeared slightly reflux,Start dropping ammonia 1665g,The temperature was dropped to 90 ,Incubated for 2 hours.After cooling to room temperature, standing stratification, discarding the water layer, washing the organic phase once,Take the organic phase is 5,5-dimethyl-2-isopropylthiazoline (), 3090g, yield 87.2%, GC content of 91%.
References:
CN106565563,2017,A Location in patent:Paragraph 0019; 0045
