ChemicalBook CAS DataBase List 5,8-Dibromoquinoline

5,8-Dibromoquinoline synthesis

10synthesis methods

Product Name:5,8-Dibromoquinoline
CAS Number:81278-86-6
Molecular formula:C9H5Br2N
Molecular Weight:286.95

3638-73-1 Synthesis

3638-73-1
201 suppliers
$10.00/1g

56-81-5 Synthesis

56-81-5
1633 suppliers
$5.00/25g

81278-86-6
46 suppliers
$46.00/1g

Yield: 90%

Reaction Conditions:

with sulfuric acid;iodine;iron(II) sulfate at 138; for 4 h;Temperature;Concentration;

Steps:

3.3
To the reaction flask was added 2.0 g of 2,5-dibromobenzene, 0.19 g of iodine, 0.17 g of ferrous sulfate, glycerol1.76 ml (dibromoaniline molar amount: glycerol mole = 1: 6), concentrated sulfuric acid44 ml (V glycerol: VConcentrated sulfuric acid = 1:25) and stirred at 138 ° C for 4 hours. After the completion of the reaction, the pH of the reaction solution was adjusted to 7.0 with lye. Ethyl acetate was extracted, dried and concentrated. The resulting crude product was purified by silica gel column eluting with a mixture of ethyl acetate and petroleum ether (V ethyl acetate: V petroleum ether = 1:19)Yield 90%.

References:

Nanjing Tech University;Yang, Wenge;Zhang, Tuan;Hu, Yonghong;Wu, Keyi;Wang, Kai;Wang, Chaoyuan;Li, Yihua CN103923102, 2017, B Location in patent:Paragraph 0036; 0041; 0046