5-ACETYL-2-METHOXYPYRIDINE, 97% synthesis
- Product Name:5-ACETYL-2-METHOXYPYRIDINE, 97%
- CAS Number:213193-32-9
- Molecular formula:C8H9NO2
- Molecular Weight:151.16
67-56-1
738 suppliers
$7.29/5ml-f
55676-22-7
267 suppliers
$7.00/100mg
213193-32-9
160 suppliers
$8.00/1g
Yield: 230 mg
Reaction Conditions:
with sodium methylate at 160; for 4 h;Microwave irradiation;
Steps:
32.1 1-(6-methoxypyrid-3-yl)ethanone
A mixture of 15 mL of methanol, 500 mg (2.89 mmol) of 1-(6-chloropyrid-3-yl)ethanone and 1.17 g (21.69 mmol) of sodium methoxide is heated in a microwave reactor at 160°C for 4 hours. The reaction medium is evaporated to dryness. After purification by chromatography on silica gel (eluent A B: heptane/EtOAc, gradient A/B: t 0 min 0% B, t 5 min 20% B, t 30 min 40% B), 230 mg of 1-(6-methoxypyrid-3-yl)ethanone were obtained, corresponding to the following characteristics: LC/MS (method G): ESI+ [M+H]+: m/z 152. tr (min) = 1.33. 1H NMR (300 MHz, δ in ppm, DMSO-d6): 2.50 (s, 3H), 3.94 (s, 3H), 6.92 (m, 1 H), 8.18 (m, 1 H), 8.83 (m, 1 H).
References:
SANOFI;EL-AHMAD, Youssef;FILOCHE-ROMME, Bruno;GANZHORM, Axel;MARCINIAK, Gilbert;MUZET, Nicolas;RONAN, Baptiste;VIVET, Bertrand;ZERR, Véronique WO2013/190123, 2013, A1 Location in patent:Page/Page column 106