5-Amino-2-trifluoromethyl-phenol synthesis

3synthesis methods

Product Name:5-Amino-2-trifluoromethyl-phenol
CAS Number:106877-47-8
Molecular formula:C7H6F3NO
Molecular Weight:177.12

3-Methoxy-4-(trifluoromethyl)phenylamine

106877-20-7
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106877-47-8
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Yield:106877-47-8 260 mg

Reaction Conditions:

with BBr₃ in 1,2-dichloro-ethane at 0 - 25; for 14 h;

Steps:

501.1 Step-1. 5-amino-2-(trifhioromethyl)phenol

BBi'3 (28.3 mL, 28.24 mmol) was added to a solution of 3-methoxy-4-(trifluoromethyl) aniline (270.0 mg, 1.41 mmol) in DCE (5.00 mL) at 0 °C. The resulting mixture was stirred at 25 °C for 14 h. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography eluting with DCM/MeOH (15/1 v/v) to obtain the title compound (260.0 mg) as a solid. LCMS (ESI): 178.00 [M+H]⁺.

References:

WO2022/99144,2022,A1 Location in patent:Paragraph 4615-4617

612498-85-8
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106877-47-8
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References

75-63-8
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591-27-5 Synthesis

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106877-46-7
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106877-45-6
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Phenol, 3-amino-2,4-bis(trifluoromethyl)-

131161-66-5
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References